Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

Background Inflammatory response has been recognized as a pivotal pathophysiological
process during cerebral ischemic stroke. NLRP3 inflammasome, involved in the regulation …

Lysine acetylation is a conserved, reversible, post-translational protein modification
regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs; also known …

Intervertebral disc degeneration (IDD) is one of the main causes of low back pain, which
seriously reduces the quality of life of patients and places a heavy economic burden on their …

Background: Experimental evidence suggests a key role of SIRT1 (silent information
regulator 1) in age-and metabolic-related vascular dysfunction. Whether these effects hold …

Ischemia-reperfusion (I/R) injury is a manifestation of tissue or organ damage that is
followed by ischemia and exacerbated by the return of blood flow to a previously damaged …

Coronary microvascular disease (CMD), which affects the arterioles and capillary
endothelium that regulate myocardial perfusion, is an increasingly recognized source of …

Intervertebral disc degeneration (IVDD) is the most common contributor to low back pain
(LBP). Recent studies have found that oxidative stress and reactive oxygen species (ROS) …

Oxidative stress is an important contributor to the development of osteoporosis. Melatonin,
an indoleamine secreted by the pineal gland, has antioxidant properties. This study aims to …