High-throughput bioinformatic analyses increasingly rely on pipeline frameworks to process
sequence and metadata. Modern implementations of these frameworks differ on three key …

The reproducibility of experiments has been a long standing impediment for further scientific
progress. Computational methods have been instrumental in drug discovery efforts owing to …

Background Microbial inhabitants of soils are important to ecosystem and planetary
functions, yet there are large gaps in our knowledge of their diversity and ecology. The …

Long noncoding RNAs (lncRNAs) are emerging as a class of important regulators
participating in various biological functions and disease processes. With the widespread …

When reporting research findings, scientists document the steps they followed so that others
can verify and build upon the research. When those steps have been described in sufficient …

Abstract Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial
Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine …

Computational reproducibility is a simple premise in theory, but is difficult to achieve in
practice. Building upon past efforts and proposals to maximize reproducibility and rigor in …

In vitro experiments provide a solid basis for understanding the interactions between
particles and biological systems. An important confounding variable for these studies is the …

Like all physical systems, biological systems are constrained by the laws of physics.
However, mathematical models of biochemistry frequently neglect the conservation of …

Background The ability of external investigators to reproduce published scientific findings is
critical for the evaluation and validation of biomedical research by the wider community …