Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …

It can be convenient to think of the genome as simply a string of nucleotides, the linear order
of which encodes an organism's genetic blueprint. However, the genome does not exist as a …

CCCTC-binding factor (CTCF) is an architectural protein involved in the three-dimensional
(3D) organization of chromatin. In this study, we assayed the 3D genomic contact profiles of …

The mammalian radiation has corresponded with rapid changes in noncoding regions of the
genome, but we lack a comprehensive understanding of regulatory evolution in mammals …

Topological domains are key architectural building blocks of chromosomes, but their
functional importance and evolutionary dynamics are not well defined. We performed …

The cohesin complex has an essential role in maintaining genome organization. However,
its role in gene regulation remains largely unresolved. Here we report that the cohesin …

Recent studies indicate that even a homogeneous population of cells display heterogeneity
in gene expression and response to environmental stimuli. Although promoter structure …

Candidate enhancers can be identified on the basis of chromatin modifications, the binding
of chromatin modifiers and transcription factors and cofactors, or chromatin accessibility …

The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function
together to shape chromatin architecture in mammalian cells, but the molecular details of …

Fate-changing transcription factors (TFs) scan chromatin to initiate new genetic programs
during cell differentiation and reprogramming. Yet the protein structure domains that allow …