The role of the monoamines serotonin and noradrenaline in mental illnesses including
depression is well recognized. All antidepressant drugs in clinical use increase acutely the …

The fear circuitry orchestrates defense mechanisms in response to environmental threats.
This circuitry is evolutionarily crucial for survival, but its dysregulation is thought to play a …

5-Hydroxytryptamine2A (serotonin2A, 5-HT2A) receptors are important for many physiologic
processes including platelet aggregation, smooth muscle contraction, and the modulation of …

5-Hydroxytryptamine2 (serotonin2, 5-HT2)-family receptors are important for mediating
many physiological functions, including vascular and nonvascular smooth muscle …

The 5-HT2A and 5-HT2C receptors belong to the G-protein-coupled receptor (GPCR)
superfamily. GPCRs transduce extracellular signals to the interior of cells through their …

Background Negative feedback regulation of the hypothalamic-pituitary-adrenal axis occurs
through a dual-receptor system of mineralocorticoid receptors (MR) and glucocorticoid …

One of the most recently identified serotonin (5-hydroxytryptamine (5-HT)) receptor subtypes
is the 5-HT 6 receptor. Although in-depth localization studies reveal an exclusive distribution …

This study investigates the possible interactions of antidepressant agents and hallucinogens
in humans through structured interviews using a standardized questionnaire. Volunteer …

Knowledge about serotonergic neurotransmission has been expanding rapidly. Recent
research has delineated 15 molecularly different serotonin receptors and multiple, discrete …

Besides demonstrated efficacy, selective serotonin reuptake inhibitors (SSRIs) hold other
advantages over earlier antidepressants such as greater tolerability and a wider range of …