Cellular cytotoxicity, the ability to kill other cells, is an important effector mechanism of the
immune system to combat viral infections and cancer. Cytotoxic T cells and natural killer …

NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and
transformed cells, being one of the main executors of cell death in the immune system. NK …

Granule exocytosis is the main pathway for the immune elimination of virus-infected cells
and tumour cells by cytotoxic T lymphocytes and natural killer cells. After target-cell …

Natural killer (NK) cells form a subset of lymphocytes that play a key role in immuno-
surveillance and host defense against cancer and viral infections. They recognize stressed …

Cytotoxic T lymphocyte and natural killer cell-initiated cell death is one of the primary
mechanisms used by higher organisms to eliminate viruses and transformed cells. In this …

The secretory granule‐mediated cell death pathway is the key mechanism for elimination of
virus‐infected and transformed target cells by cytotoxic lymphocytes. The formation of the …

The granzyme B-induced cell death has been traditionally viewed as a primary mechanism
that is used by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells to eliminate …

Human granzyme B (GrB) released from cytotoxic lymphocytes plays a key role in the
induction of target cell apoptosis when internalized in the presence of perforin. Here we …

Cytotoxic T lymphocytes (CTL) kill malignant and infected cells through the directed release
of cytotoxic proteins into the immunological synapse (IS). The cytotoxic protein granzyme B …

Neutrophil serine proteases are granule-associated enzymes known mainly for their function
in the intracellular killing of pathogens. Their extracellular release upon neutrophil activation …