The desmosome is a cell–cell adhesive junction that provides integrity and mechanical
resistance to tissues through its attachment to the intermediate filament cytoskeleton …

Desmosomes are relatives of ancient cadherin-based junctions, which emerged late in
evolution to ensure the structural integrity of vertebrate tissues by coupling the intermediate …

Introduction Pemphigus is an autoantibody driven disease that impairs the barrier function of
the skin and mucosa by disrupting desmosomes and thereby impeding cellular cohesion. It …

Cell-cell junctions, and specifically desmosomes, are crucial for robust intercellular
adhesion. Desmosomal function is compromised in the autoimmune blistering skin disease …

We suggest that the human body can be viewed as of textile nature whose fabric consists of
interconnected fiber systems. These fiber systems form highly dynamic scaffolds, which …

Cell junctions integrate extracellular signals with intracellular responses to polarize tissues,
pattern organs, and maintain tissue architecture by promoting cell–cell adhesion and …

Stem cells (SCs) are critical to maintain tissue homeostasis. However, it is currently not
known whether signaling through cell junctions protects quiescent epithelial SC reservoirs …

Zinc oxide nanoparticles (ZNPs) are widely used in sunscreens and nanomedicines, and it
was recently confirmed that ZNPs can penetrate stratum corneum into deep epidermis …

L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted
effects, including the generation of hydrogen peroxide (H2O2) during oxidative reactions …

As the outermost layer of the skin, the epidermis is an essential barrier against mechanical
insult, water loss, infection from microbial pathogens, exposure to toxins, and UVR from …