GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease

MO Nava-Mesa, L Jiménez-Díaz, J Yajeya… - Frontiers in cellular …, 2014 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two …

[HTML][HTML] Cigarette smoking impairs nitric oxide-mediated cerebral blood flow increase: Implications for Alzheimer's disease

N Toda, T Okamura - Journal of pharmacological sciences, 2016 - Elsevier
Cerebral blood flow is mainly regulated by nitrergic (parasympathetic, postganglionic)
nerves and nitric oxide (NO) liberated from endothelial cells in response to shear stress and …

Genomic and morphological changes of neuroblastoma cells in response to three-dimensional matrices

GN Li, LL Livi, CM Gourd, ES Deweerd… - Tissue …, 2007 - liebertpub.com
Advances in neural tissue engineering require a comprehensive understanding of neuronal
growth in 3 dimensions. This study compared the gene expression of SH-SY5Y human …

Nicotinic modulation of innate immune pathways via α7 nicotinic acetylcholine receptor

WY Cui, MD Li - Journal of neuroimmune pharmacology, 2010 - Springer
The major addictive component of tobacco, nicotine, exerts anti-inflammatory effects in
multiple cell types and may benefit neurons in various degenerative disorders, such as …

The role of neurogenesis in neurodegenerative diseases and its implications for therapeutic development

A Abdipranoto, S Wu, S Stayte… - CNS & Neurological …, 2008 - ingentaconnect.com
Neurodegenerative diseases are characterised by a net loss of neurons from specific
regions of the central nervous system (CNS). Until recently, research has focused on …

Neuroprotective and neurotoxic effects of nicotine

S Ferrea, G Winterer - Pharmacopsychiatry, 2009 - thieme-connect.com
The interest in the action of nicotine in the central nervous system (CNS) has significantly
increased during the past 15 years. This is due in part to the growing importance of nicotine …

Nicotine‐induced protein expression profiling reveals mutually altered proteins across four human cell lines

JA Paulo, SP Gygi - Proteomics, 2017 - Wiley Online Library
Mass spectrometry‐based proteomic strategies can profile the expression level of proteins in
response to external stimuli. Nicotine affects diverse cellular pathways, however, the …

Nicotinic receptor agonists and antagonists increase sAPPα secretion and decrease Aβ levels in vitro

M Mousavi, E Hellström-Lindahl - Neurochemistry international, 2009 - Elsevier
We have earlier reported that Aβ were significantly reduced in brains of smoking Alzheimer
patients and control subjects compared with non-smokers, as well as in nicotine treated …

NeuroHIV and use of addictive substances

SL Chang, KP Connaghan, Y Wei, MD Li - International review of …, 2014 - Elsevier
In the past three decades, substance abuse has been identified as a key comorbidity of
human immunodeficiency virus-1 (HIV-1) infection. Many studies have found that the use …

[HTML][HTML] Unique effects of nicotine across the lifespan

M Ren, S Lotfipour, F Leslie - Pharmacology Biochemistry and Behavior, 2022 - Elsevier
Smoking remains the leading cause of preventable death in the United States. Although
combustible cigarettes are largely being replaced by tobacco-free products, nicotine use …