Function and role of regulatory T cells in rheumatoid arthritis
Q Jiang, G Yang, Q Liu, S Wang, D Cui - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with
symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune …
symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune …
DNA methylation as a transcriptional regulator of the immune system
DNA methylation is a dynamic epigenetic modification with a prominent role in determining
mammalian cell development, lineage identity, and transcriptional regulation. Primarily …
mammalian cell development, lineage identity, and transcriptional regulation. Primarily …
Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models
SJ Yang, AK Singh, T Drow, T Tappen… - Science Translational …, 2022 - science.org
Adoptive transfer of regulatory T cells (Tregs) is therapeutic in type 1 diabetes (T1D) mouse
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …
Extracellular adenosine-mediated modulation of regulatory T cells
A Ohta, M Sitkovsky - Frontiers in immunology, 2014 - frontiersin.org
Extracellular adenosine-dependent suppression and redirection of pro-inflammatory
activities are mediated by the signaling through adenosine receptors on the surface of most …
activities are mediated by the signaling through adenosine receptors on the surface of most …
The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome
Regulatory T cells (Tregs) are suppressive T cells that have an essential role in maintaining
the balance between immune activation and tolerance. Their development, either in the …
the balance between immune activation and tolerance. Their development, either in the …
mTOR signaling, Tregs and immune modulation
NM Chapman, H Chi - Immunotherapy, 2014 - Taylor & Francis
Foxp3+ Tregs are central regulators of immune tolerance. As dysregulated Treg responses
contribute to disease pathogenesis, novel approaches to target the immunomodulatory …
contribute to disease pathogenesis, novel approaches to target the immunomodulatory …
Dominant role for regulatory T cells in protecting females against pulmonary hypertension
R Tamosiuniene, O Manouvakhova… - Circulation …, 2018 - Am Heart Assoc
Rationale: Pulmonary arterial hypertension (PH) is a life-threatening condition associated
with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it is currently …
with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it is currently …
Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function
KA Helmin, L Morales-Nebreda… - The Journal of …, 2020 - Am Soc Clin Investig
Tregs require Foxp3 expression and induction of a specific DNA hypomethylation signature
during development, after which Tregs persist as a self-renewing population that regulates …
during development, after which Tregs persist as a self-renewing population that regulates …
Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells
P Pandiyan, J Zhu - Cytokine, 2015 - Elsevier
Abstract CD4+ CD25+ Foxp3+ regulatory cells (T regs) are a special lineage of cells central
in the maintenance of immune homeostasis, and are targeted for human immunotherapy …
in the maintenance of immune homeostasis, and are targeted for human immunotherapy …
The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
B Liu, OC Salgado, S Singh, KL Hippen… - Nature …, 2019 - nature.com
Regulatory T (Treg) cells control self-tolerance, inflammatory responses and tissue
homeostasis. In mature Treg cells, continued expression of FOXP3 maintains lineage …
homeostasis. In mature Treg cells, continued expression of FOXP3 maintains lineage …