Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …

Besides their role in cell metabolism, mitochondria display many other functions.
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …

Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …

Inflammatory processes are primary contributors to the development and progression of
alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non …

Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and
microRNAs. They can originate from both healthy and stressed cells, and provide a …

Mitochondrial damage plays vital roles in the pathology of many diseases, such as cancers,
neurodegenerative diseases, aging, metabolic diseases and many types of organ injury …

Background and Aims Nonalcoholic fatty liver disease encompasses a spectrum of diseases
ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis, and liver …

Despite the emergence of mitochondria as key regulators of innate immunity, the
mechanisms underlying the generation and release of immunostimulatory alarmins by …

Mitochondria are indispensable organelles for maintaining cell energy metabolism, and also
are necessary to retain cell biological function by transmitting information as signal …

Heavy alcohol use is the cause of alcoholic liver disease (ALD). The ALD spectrum ranges
from alcoholic steatosis to steatohepatitis, fibrosis, and cirrhosis. In Western countries …