Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

The histaminergic system in the brain is a phylogenetically old group of neurons that project
to most of the central nervous system. It holds a key position in the regulation of basic body …

Among the four G protein–coupled receptors (H1–H4) identified as mediators of the biologic
effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive …

In superfused mouse striatal slices preincubated with [3 H] dopamine 25 nmol/l, the
electrically (3 Hz) evoked tritium overflow was inhibited by histamine 10 μmol/l by 18%. The …

Narcolepsy is characterized by excessive daytime sleepiness (EDS), cataplexy, direct
onsets of rapid eye movement (REM) sleep from wakefulness (DREMs) and deficiency of …

Whether the job is waking the brain after a peaceful sleep, initiating gastric secretion when
dinner is served or orchestrating the elements of inflammation after a mosquito bite …

Presynaptic H3 receptors occur on histaminergic neurones of the CNS (autoreceptors) and
on non‐histaminergic neurones of the central and autonomic nervous system …

Neuropharmacology of the histaminergic neuron system in the brain and its relationship with
behavioral disorders - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & …

Histaminergic neurons play an important role in the regulation of sleep–wake behavior
through histamine H1 receptors (H1R). Blockade of the histamine H3 receptor (H3R) is …

The substantia nigra pars reticulata (SNr) plays a key role in basal ganglia function.
Projections from multiple basal ganglia nuclei converge at the SNr to regulate nigrothalamic …