Association of neutrophil mediators with dengue disease severity and cardiac impairment in adults

PY Chia, A Teo, TW Yeo - The Journal of Infectious Diseases, 2022 - academic.oup.com
Background Cardiac impairment contributes to hypotension in severe dengue (SD).
However, studies examining pathogenic factors affecting dengue-associated cardiac …

[HTML][HTML] Clinical and prognostic relevance of sST2 in adults with dengue-associated cardiac impairment and severe dengue

A Teo, PY Chia, GK Ramireddi… - PLOS Neglected …, 2022 - journals.plos.org
Background Dengue can be complicated by severe outcomes including cardiac impairment,
and the lack of reliable prognostic biomarkers poses a challenge in managing febrile …

Higher‐temperature‐adapted dengue virus serotype 2 strain exhibits enhanced virulence in AG129 mouse model

A Modak, SR Mishra, M Awasthi, S Sreedevi… - The FASEB …, 2023 - Wiley Online Library
The factors that drive dengue virus (DENV) evolution, and selection of virulent variants are
yet not clear. Higher environmental temperature shortens DENV extrinsic incubation period …

[HTML][HTML] Immunocompetent mice infected by two lineages of dengue virus type 2: observations on the pathology of the lung, heart and skeletal muscle

FC Jácome, GC Caldas, AC Rasinhas, ALT de Almeida… - Microorganisms, 2021 - mdpi.com
Dengue virus (DENV) infection by one of the four serotypes (DENV-1 to 4) may result in a
wide spectrum of clinical manifestations, with unpredictable evolution and organ …

[HTML][HTML] Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury

AC Rasinhas, FC Jácome, GC Caldas… - Memórias do Instituto …, 2023 - SciELO Brasil
BACKGROUND Dengue is a disease caused by dengue virus (DENV-1 through-4). Among
the four serotypes, DENV-4 remains the least studied. Acute kidney injury is a potential …

miR-21 Overexpression Ameliorates the Myocardial Injury and Inflammation and Oxidative Stress

C Lu, G Jiang, X Zhao - Journal of Biomaterials and Tissue …, 2022 - ingentaconnect.com
This study assessed the effect of miR-21 overexpression on the myocardial injury and
inflammation and oxidative stress. Bone marrow mesenchymal stem cells (BMSCs) of rats …

Estudos do tropismo de duas linhagens do vírus dengue tipo 2 em modelo experimental murino: análises clínicas, bioquímicas e morfológicas

FC Jácome - 2021 - arca.fiocruz.br
A dengue é a arbovirose mais prevalente entre humanos e quatro bilhões de pessoas
vivem sob risco de infecção. As manifestações clínicas da dengue são variáveis, e a doença …

miR-663-Containing Exosomes Secreted by Bone Marrow Mesenchymal Stem Cells Ameliorate Cardiomyocyte Oxidative Damage

X Xia, B Xu - Journal of Biomaterials and Tissue Engineering, 2023 - ingentaconnect.com
This study assesses the role of miR-663 in the oxidative damage in myocardial cells through
regulating BMSC from exosome. BMSC from rats was cultivated and transfected with miR …

[HTML][HTML] COVID-19 and the Beat-To-Beat Heart

DS Souza, AO Durço, CSG Rocha… - International Journal of …, 2022 - SciELO Brasil
Since December 2019, the coronavirus disease (COVID-19) has caused an exponential
increase in acute respiratory syndrome cases and has rapidly spread to more than 210 …

Endothelial damage and cardiac dysfunction in the pathophysiology of severe dengue in adults

PY Chia - 2022 - dr.ntu.edu.sg
Dengue infection is the most abundant arbovirus infection globally, affecting more than half
the world's population and is predicted to increase with climate change. Disease caused by …