This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

Mapping of homozygous deletions on human chromosome 10q23 has led to the isolation of
a candidate tumor suppressor gene, PTEN, that appears to be mutated at considerable …

Cancer cells possess a broad spectrum of migration and invasion mechanisms. These
include both individual and collective cell-migration strategies. Cancer therapeutics that are …

Responses of cells to mechanical properties of the adhesion substrate were examined by
culturing normal rat kidney epithelial and 3T3 fibroblastic cells on a collagen-coated …

Cells reside in a protein network, the extracellular matrix (ECM), which they secrete and
mold into the intercellular space. The ECM exerts profound control over cells. The effects of …

Estrogens play a critical role in many aspects of physiology, particularly female reproductive
function, but also in pathophysiology, and are associated with protection from numerous …

Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

Integrin-mediated cell adhesions provide dynamic, bidirectional links between the
extracellular matrix and the cytoskeleton. Besides having central roles in cell migration and …