Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

▪ Abstract Chloride secretion is the major determinant of mucosal hydration thoughout the
gastrointestinal tract, and chloride transport is also pivotal in the regulation of fluid secretion …

Tubular reabsorption of filtered sodium is quantitatively the main contribution of kidneys to
salt and water homeostasis. The transcellular reabsorption of sodium proceeds by a two …

The mechanisms underlying acid–base transfers across the branchial epithelium of fishes
have been studied for more than 70 years. These animals are able to compensate for …

The NHE family of ion exchangers includes six isoforms (NHE1–NHE6) that function in an
electroneutral exchange of intracellular H+ for extracellular Na+. This review focuses on the …

Four isoforms of the Na+/H+ exchanger (NHE6–NHE9) are distributed to intracellular
compartments in human cells. They are localized to Golgi and post-Golgi endocytic …

Ejection of intracellular H in exchange for external Na is the most effective means of
eliminating excess acid from actively metabolizing cells. Na/H exchange is also crucial for …

▪ Abstract The sodium/hydrogen exchange (NHE) gene family plays an integral role in
neutral sodium absorption in the mammalian intestine. The NHE gene family is comprised of …

This review describes recent progress concerning the molecular aspects of the Na+/H+
exchanger. The Na+/H+ exchanger is an important regulator for intracellular pH, cell volume …

Abstract Na+-glucose cotransporter 1 (SGLT1)-mediated glucose uptake leads to activation
of Na+-H+ exchanger 3 (NHE3) in the intestine by a process that is not dependent on …