RNA structure is crucial for gene regulation and function. In the past, transcriptomes have
largely been parsed by primary sequences and expression levels, but it is now becoming …

RNA performs and regulates a diverse range of cellular processes, with new functional roles
being uncovered at a rapid pace. Interest is growing in how these functions are linked to …

RNA is arguably the most versatile biological macromolecule because of its ability both to
encode and to manipulate genetic information. The diverse roles of RNA depend on its …

Chemical probing of RNA and DNA structure is a widely used and highly informative
approach for examining nucleic acid structure and for evaluating interactions with protein …

Long non-coding RNAs (lncRNAs) are recently-discovered transcripts that regulate vital
cellular processes and are crucially connected to diseases. Despite their unprecedented …

The long non-coding RNA (lncRNA) Xist is a master regulator of X-chromosome inactivation
in mammalian cells. Models for how Xist and other lncRNAs function depend on …

Identifying small molecules that selectively bind to structured RNA motifs remains an
important challenge in developing potent and specific therapeutics. Most strategies to find …

Transcriptomics experiments and computational predictions both enable systematic
discovery of new functional RNAs. However, many putative noncoding transcripts arise …

For decades, dimethyl sulfate (DMS) mapping has informed manual modeling of RNA
structure in vitro and in vivo. Here, we incorporate DMS data into automated secondary …

The continual improvement of methods for RNA 3D structure modeling and prediction
requires accurate and statistically meaningful data concerning RNA structure, both for …