Cancer stem cells (CSCs) are a subpopulation of tumor cells that possess unique self-
renewal activity and mediate tumor initiation and propagation. The PI3K/Akt/mTOR signaling …

Heterogeneity is an omnipresent feature of mammalian cells in vitro and in vivo. It has been
recently realized that even mouse and human embryonic stem cells under the best culture …

Background Ovarian cancer is the most common malignant tumor of the female reproductive
tract. Chemoresistance is a major challenge for current ovarian cancer therapy. However …

Background & Aims Almost all gastric cancers are adenocarcinomas, which have
considerable heterogeneity among patients. We sought to identify subtypes of gastric …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

Mammalian target of rapamycin (mTOR) is a Ser/Thr kinase that regulates a wide range of
functions, including cell growth, proliferation, survival, autophagy, metabolism, and …

Curcumin has been shown to have a wide variety of therapeutic effects, ranging from anti-
inflammatory, chemopreventive, anti-proliferative, and anti-metastatic. This review provides …

Prostate and breast cancer are the two cancers with the highest incidence in men and
women, respectively. Here, we focus on the known biology of acquired resistance to …

Radiotherapy is a curative treatment option in prostate cancer. Nevertheless, patients with
high-risk prostate cancer are prone to relapse. Identification of the predictive biomarkers and …

The chemokine CXCL12 (SDF-1) and its cell surface receptor CXCR4 were first identified as
regulators of lymphocyte trafficking to the bone marrow. Soon after, the CXCL12/CXCR4 …