Neutrophil migration and its role during inflammation has been the focus of increased
interest in the past decade. Advances in live imaging and the use of new model systems …

Despite tremendous advancements in technologies and resources, drug discovery still
remains a tedious and expensive process. Though most cells are cultured using 2D …

The immune system protects organisms against endogenous and exogenous harm and
plays a key role in tissue development, repair and regeneration. Traditional …

A review with 105 references that analyzes the emerging research area of 3D cell culture in
microfluidic platforms with integrated detection schemes. Over the last several decades a …

Neutrophils are the most abundant type of leukocytes in the blood, traditionally regarded as
the first immune responders to infections and inflammations. In the context of tumors …

Neutrophil recruitment is not only vital for host defense, but also relevant in pathological
inflammatory reactions, such as sepsis. Model systems have been established to examine …

Cell motility is required for diverse biological processes including development, homing of
immune cells, wound healing, and cancer cell invasion. Motile neutrophils exhibit a …

Inflammatory diseases are often characterised by excessive neutrophil infiltration from the
blood stream to the site of inflammation, which damages healthy tissue and prevents …

Neutrophils are fast-moving cells essential for host immune functions. Although they
primarily rely on glycolysis for ATP, isolated primary human neutrophils depend on …

Distinct integrin activation pathways for effector and regulatory T cell trafficking and function |
Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …