The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …

Tamoxifen is commonly used for the treatment of patients with estrogen receptor‐positive
(ER+) breast cancer, but the acquired resistance to tamoxifen presents a critical challenge of …

“Structure subserves function” is one fundamental biological maxim, and so the biological
membrane that delimits the regions primarily serves as the margin between life and death …

Background Myocardial microvascular injury is the key event in early diabetic heart disease.
The injury of myocardial microvascular endothelial cells (CMECs) is the main cause and …

Mitochondria are key regulators of cell survival and are involved in a plethora of
mechanisms, such as metabolism, Ca2+ signaling, reactive oxygen species (ROS) …

Energy metabolism reprogramming is the characteristic feature of tumors. The
tumorigenesis, metastasis, and drug resistance of ovarian cancer (OC) is dependent on …

An increasing number of studies have demonstrated the significant roles of the interplay
between microenvironmental mechanics in tissues and biochemical-genetic activities in …

Background: UVB irradiation can cause acute damage such as sunburn, or photoaging and
melanoma, all of which are major health threats. Objective: This study was designed to …

The discovery of MICU1 as gatekeeper of mitochondrial calcium (m Ca 2+) entry has
transformed our understanding of m Ca 2+ flux. Recent studies revealed an additional role …