Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

Systemic sclerosis (SSc), also known as scleroderma, is a rare connective tissue disease
characterized by vascular and immune dysfunction, leading to fibrosis that can damage …

Importance High-dose immunosuppressive therapy and autologous hematopoietic stem cell
transplantation (HSCT) have shown efficacy in systemic sclerosis in phase 1 and small …

In 1997, the first consensus guidelines for haematopoietic SCT (HSCT) in autoimmune
diseases (ADs) were published, while an international coordinated clinical programme was …

Background Autologous hematopoietic stem cell transplantation has been used since 1996
for the treatment of severe autoimmune diseases refractory to approved therapies. We …

Autologous haematopoietic stem cell transplantation (HSCT) is the only treatment that is
able to induce long-term, drug-free and symptom-free remission in several refractory …

Autoimmune and inflammatory phenomena are characteristically present in systemic
sclerosis (SSc) and impact on dysregulated fibroblast extracellular matrix deposition …

To evaluate the immunological mechanisms associated with clinical outcomes after
autologous hematopoietic stem cell transplantation (AHSCT), focusing on regulatory T …

Objective: Systemic sclerosis (SSc) is a generalised autoimmune disease, causing morbidity
and a reduced life expectancy, especially in patients with rapidly progressive diffuse …

To specify the incidence and risk factors for secondary autoimmune diseases (ADs) after
HSCT for a primary AD, we retrospectively analyzed AD patients treated by HSCT reported …