[HTML][HTML] The paradox of HIV blood–brain barrier penetrance and antiretroviral drug delivery deficiencies
HIV attacks the body's immune cells, frequently compromises the integrity of the blood–brain
barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB …
barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB …
Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS
In spite of significant advances in antiretroviral (ARV) therapy, the elimination of human
immunodeficiency virus (HIV) reservoirs from the periphery and the central nervous system …
immunodeficiency virus (HIV) reservoirs from the periphery and the central nervous system …
Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system
HIV-associated neurocognitive disorder (HAND), characterized by a wide spectrum of
behavioral, cognitive, and motor dysfunctions, continues to affect approximately 50% of HIV …
behavioral, cognitive, and motor dysfunctions, continues to affect approximately 50% of HIV …
[HTML][HTML] The transport of anti-HIV drugs across blood–CNS interfaces: summary of current knowledge and recommendations for further research
L Varatharajan, SA Thomas - Antiviral research, 2009 - Elsevier
The advent of highly active antiretroviral therapy (HAART), which constitutes HIV protease
inhibitors, nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase …
inhibitors, nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase …
Nanotechnology-based systems for the treatment and prevention of HIV/AIDS
J das Neves, MM Amiji, MF Bahia… - Advanced drug delivery …, 2010 - Elsevier
The HIV/AIDS pandemic is an increasing global burden with devastating health-related and
socioeconomic effects. The widespread use of antiretroviral therapy has dramatically …
socioeconomic effects. The widespread use of antiretroviral therapy has dramatically …
[HTML][HTML] How much do antiretroviral drugs penetrate into the central nervous system?
L Ene, D Duiculescu, SM Ruta - Journal of medicine and life, 2011 - ncbi.nlm.nih.gov
The central nervous system can act as a compartment in which HIV can replicate
independently from plasma, and also as a sanctuary in which, under suboptimal drug …
independently from plasma, and also as a sanctuary in which, under suboptimal drug …
Antiretroviral drug concentrations in brain tissue of adult decedents
Objective: Determine concentrations of antiretroviral therapy (ART) drugs in the human
brain. Design: Cohort study of persons with HIV who consented to antemortem assessment …
brain. Design: Cohort study of persons with HIV who consented to antemortem assessment …
Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta
Objective and design: Tenofovir (TFV) is used in pregnant women as a part of combination
antiretroviral treatment to prevent mother-to-child transmission of HIV infection. We aimed to …
antiretroviral treatment to prevent mother-to-child transmission of HIV infection. We aimed to …
Diketopiperazines as a tool for the study of transport across the blood− brain barrier (BBB) and their potential use as BBB-shuttles
M Teixidó, E Zurita, M Malakoutikhah… - Journal of the …, 2007 - ACS Publications
Here we prepared and evaluated two libraries of mono-N-methylated and di-N-methylated
diketopiperazines (DKPs) by parallel artificial membrane permeability assay and …
diketopiperazines (DKPs) by parallel artificial membrane permeability assay and …
Low cerebrospinal fluid concentrations of the nucleotide HIV reverse transcriptase inhibitor, tenofovir
BM Best, SL Letendre, P Koopmans… - JAIDS Journal of …, 2012 - journals.lww.com
Background: Tenofovir is a nucleotide HIV reverse transcriptase inhibitor whose chemical
properties suggest that it may not penetrate into the central nervous system in therapeutic …
properties suggest that it may not penetrate into the central nervous system in therapeutic …