Spirooxindole: a versatile biologically active heterocyclic scaffold

SS Panda, AS Girgis, MN Aziz, MS Bekheit - Molecules, 2023 - mdpi.com
Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural
spirooxindole-containing compounds have been identified as bio-promising agents …

The chemistry of heterocycles in the 21st century

VN Charushin, EV Verbitskiy, ON Chupakhin… - Uspekhi Khimii, 2024 - mathnet.ru
The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …

C3-spirooxindoles: Divergent chemical synthesis and bioactivities (2018–2023)

MH Helal, ME Owda, AT Mogharbel, AH Alessa… - Bioorganic …, 2024 - Elsevier
This scientific review documents the recent progress of C 3-spirooxindoles chemistry
(synthesis and reaction mechanism) and their bioactivities, focusing on the promising results …

[4+ 2]-Cycloaddition to 5-Methylidene-Hydantoins and 5-Methylidene-2-Thiohydantoins in the Synthesis of Spiro-2-Chalcogenimidazolones

DE Shybanov, ME Kukushkin, YS Hrytseniuk… - International Journal of …, 2023 - mdpi.com
Novel hydantion and thiohydantoin-based spiro-compounds were prepared via theDiels–
Alder reactions between 5-methylidene-hydantoins or 5-methylidene-2-thiohydantoins and …

Diffusion mixing with a volatile tertiary amine as a very efficient technique for 1, 3-dipolar cycloaddition reactions proceeding via dehydrohalogenation of stable …

DE Shybanov, ME Filkina, ME Kukushkin… - New Journal of …, 2022 - pubs.rsc.org
Spontaneous diffusion of volatile reagent vapors into a solution, containing a stable
precursor of an unstable reactive intermediate, may be the simplest method for carrying out …

Small Molecules with Spiro-Conjugated Cycles: Advances in Synthesis and Applications

EK Beloglazkina - International Journal of Molecular Sciences, 2023 - mdpi.com
Dear Colleagues, The purpose of this Special Issue was to attract the attention of
researchers to the features of the synthesis and physico-chemical and biological …

Asymmetric Metal‐Templated Route to Amino Acids with 3‐Spiropyrrolidine Oxindole Core via a 1, 3‐Dipolar Addition of Azomethine Ylides to a Chiral …

ZT Gugkaeva, MV Panova… - Advanced Synthesis …, 2022 - Wiley Online Library
We herein developed a protocol for the asymmetric synthesis of artificial AAs featuring a 3‐
spiropyrrolidine oxindole skeletal with continuous tetrasubstituted carbon stereocenters by a …

Organic Chemistry in Russian Universities. Achievements of Recent Years

II Stoikov, IS Antipin, VA Burilov… - Russian Journal of …, 2024 - Springer
An overview of the main scientific achievements of Russian universities in the field of
organic chemistry over the period 2018–2023 is presented.

Synthesis and evaluation of some new imidazolone bearing phthalyl and tosyl amino acids moities as anti-cancer agents supported by molecular docking

S Ragab, AF Wasfy, MS Amine… - Egyptian Journal of …, 2024 - journals.ekb.eg
A facile and convenient synthesis of imidazolone-incorporated phthalyl and/or p-tosyl amino
acid derivatives was described. The reaction of oxazolone derivative 2 with p …

[HTML][HTML] Women in Bioorganic Chemistry

F Cardona, C Parmeggiani, C Matassini - Molecules, 2022 - mdpi.com
We are very happy to present this Special Issue, for which we acted as guest editors, and
which includes scientific contributions from laboratories headed by women active in the field …