Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …

Tumor-associated macrophages (TAM) in the tumor microenvironment (TME) cooperate with
cancer stem cells (CSC) to maintain stemness. We recently identified cluster of …

Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic
behavior and induction mechanisms of CSCs are not well understood. Here, we employ …

Background A better understanding of the molecular mechanism involving lncRNA-miRNA-
mRNA network underlying glioma genesis is beneficial to the treatment of glioma. This study …

The tumor microenvironment has been recently reported to play a pivotal role in sustaining
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …

Radiotherapy is one of the most common treatments for oral cancer. However, in the clinic,
recurrence and metastasis of oral cancer occur after radiotherapy, and the underlying …

Head and neck cancer (HNC) is mainly treated by surgery, radiotherapy, and adjuvant
chemotherapy; however, the prognosis of some patients with HNC is poor because of …

Tumor progression is associated with dedifferentiated histopathologies concomitant with
cancer cell survival within a changing, and often hostile, tumor microenvironment. These …