The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40
years ago through the study of tyrosine kinase growth factor receptors, are now known to …

A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic
potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be …

Cell surface receptor uptake via clathrin-mediated endocytosis (CME) and subsequent
intracellular sorting for degradation or recycling regulates the strength and specificity of …

The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …

It is generally assumed that cells interrogate the mechanical properties of their environment
by pushing and pulling on the extracellular matrix (ECM). For instance, acto-myosin …

Despite a well-established role for the epidermal growth factor receptor (EGFR) in
tumorigenesis, EGFR activities and endocytosis in tumors in vivo have not been studied. We …

Oxymatrine (OMT) is a quinolizidine alkaloid derived from the roots of the Sophora genus
plants. It has been widely used as a treatment for chronic hepatitis infections and …

Clathrin mediated endocytosis (CME) is the main route of receptor internalization in
mammalian cells and this well conserved mechanism has been intensively studied for over …

Methods to acutely manipulate protein interactions at the subcellular level are powerful tools
in cell biology. Several blue-light-dependent optical dimerization tools have been …