New World arenavirus biology

N Sarute, SR Ross - Annual review of virology, 2017 - annualreviews.org
Hemorrhagic fevers caused by viruses were identified in the late 1950s in South America.
These viruses have existed in their hosts, the New World rodents, for millions of years. Their …

Hemorrhagic fever-causing arenaviruses: lethal pathogens and potent immune suppressors

ME Brisse, H Ly - Frontiers in immunology, 2019 - frontiersin.org
Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally
been neglected as tropical diseases primarily affecting African and South American regions …

Clinical sequencing uncovers origins and evolution of Lassa virus

KG Andersen, BJ Shapiro, CB Matranga, R Sealfon… - Cell, 2015 - cell.com
Summary The 2013–2015 West African epidemic of Ebola virus disease (EVD) reminds us
of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) …

It's in the mix: Reassortment of segmented viral genomes

AC Lowen - PLoS Pathogens, 2018 - journals.plos.org
Segmentation of viral genomes allows exchange of intact genes between related viruses
when they coinfect the same cell (Fig 1). This exchange is a type of recombination called …

Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy

SM Kallert, S Darbre, WV Bonilla, M Kreutzfeldt… - Nature …, 2017 - nature.com
Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte
(CTLeff) responses. Conversely, the induction of protective tumour-specific CTLeff and their …

Reassortment events in the evolution of hantaviruses

B Klempa - Virus genes, 2018 - Springer
Abstract Hantaviruses (order Bunyavirales, family Hantaviridae), known as important
zoonotic human pathogens, possess the capacity to exchange genome segments via …

Identification of reptarenaviruses, hartmaniviruses, and a novel chuvirus in captive native Brazilian boa constrictors with boid inclusion body disease

FF Argenta, J Hepojoki, T Smura, L Szirovicza… - Journal of …, 2020 - Am Soc Microbiol
Boid inclusion body disease (BIBD) is a transmissible viral disease of captive snakes that
causes severe losses in snake collections worldwide. It is caused by reptarenavirus …

Characterization of Haartman Institute snake virus-1 (HISV-1) and HISV-like viruses—The representatives of genus Hartmanivirus, family Arenaviridae

J Hepojoki, S Hepojoki, T Smura, L Szirovicza… - PLoS …, 2018 - journals.plos.org
The family Arenaviridae comprises three genera, Mammarenavirus, Reptarenavirus and the
most recently added Hartmanivirus. Arenaviruses have a bisegmented genome with …

Differential disease susceptibilities in experimentally reptarenavirus-infected boa constrictors and ball pythons

MD Stenglein, D Sanchez-Migallon Guzman… - Journal of …, 2017 - Am Soc Microbiol
Inclusion body disease (IBD) is an infectious disease originally described in captive snakes.
It has traditionally been diagnosed by the presence of large eosinophilic cytoplasmic …

Metagenomic investigation of idiopathic meningoencephalomyelitis in dogs

LL Hoon‐Hanks, S McGrath, KL Tyler… - Journal of veterinary …, 2018 - Wiley Online Library
Background Meningoencephalomyelitis of unknown origin (MUO) is a common and life‐
threatening neuroinflammatory disease in dogs. Features of the disease are suggestive of …