Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a
programme of proliferation that is closely linked with the acquisition of effector functions and …

Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a
decade ago, the NFAT family of transcription factors has grown to include five members. It …

To fulfill the bioenergetic and biosynthetic demand of proliferation, T cells reprogram their
metabolic pathways from fatty acid β-oxidation and pyruvate oxidation via the TCA cycle to …

How and when memory T cells form during an immune response are long-standing
questions. To better understand memory CD8 T cell development, a time course of gene …

The murine homologue of the previously identified human" pre‐B‐cell colony‐enhancing
factor"(PBEF) gene coding for a putative cytokine has been identified by screening a …

In lymphocytes, integration of Ca 2+ and other signaling pathways results in productive
activation, while unopposed Ca 2+ signaling leads to tolerance or anergy. We show that the …

Modulation of many signaling pathways in antigen-stimulated T and B cells results in global
changes in gene expression. Here we investigate the contribution of calcium signaling to …

In cells undergoing apoptosis, mitochondrial outer-membrane permeabilization (MOMP) is
followed by caspase activation promoted by released cytochrome c. Although caspases …

Dendritic cells (DCs) are strong activators of primary T cell responses. Their priming ability is
acquired upon encounter with maturation stimuli. To identify the genes that are differentially …

The immunologic specificity of the antigen receptors of T cells and B cells is the result of
random shuffling of the many genes that form the DNA code for the antigen-binding site of …