Retinal degenerative diseases are a leading cause of visual impairment or blindness. There
are many therapies for delaying the progression of vision loss but no curative strategies …

Animal models with pharmacologically induced retinal degeneration including sodium
iodate (NaIO3) and N-methyl-N-nitrosourea (MNU) have been extensively used in …

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly.
Dry AMD is characterized by a progressive macular degeneration of the retinal pigment …

Structural designing of carriers with extended drug release profiles is critically important for
achieving long-acting drug delivery systems toward efficient managements of chronic …

Purpose: The lack of suitable animal models for (dry) age-related macular degeneration
(AMD) has hampered therapeutic research into the disease, so far. In this study, pigmented …

We sought to develop and characterize outer retinal degeneration induced by intravitreal
injection of sodium iodate (SI) after vitrectomy in rabbits. To determine the effective dose of …

Sodium iodate (NaIO 3) is a commonly used model for age-related macular degeneration
(AMD), but its rapid and severe induction of retinal pigment epithelial (RPE) and …

Since genetic models for retinal degeneration (RD) in animals larger than rodents have not
been firmly established to date, we sought in the present study to develop a new rabbit …

Sodium iodate (NaIO3) has been shown to cause severe oxidative stress damage to retinal
pigment epithelium cells. This results in the indirect death of photoreceptors, leading to a …

Dysfunction and death of retinal pigment epithelium (RPE) and or photoreceptors can lead
to irreversible vision loss. The eye represents an ideal microenvironment for stem cell …