The poly-l-proline type II (PPII) helix in recent years has emerged clearly as a structural class
not only of fibrillar proteins (in collagen, PPII is a dominant conformation) but also of the …

Human-made information relay systems invariably incorporate central regulatory
components, which are mirrored in biological systems by dense feedback and feedforward …

Peptide-protein interactions contribute a significant fraction of the protein-protein
interactome. Accurate modeling of these interactions is challenging due to the vast …

Introduction 3. Conventional and atypical sequence motifs 3.1. Canonical peptide motifs
recognized by the SH3 domains 3.2. Atypical SH3-binding motifs 3.3. The RxxK motif 4 …

The GIT proteins, GIT1 and GIT2, are GTPase-activating proteins (inactivators) for the ADP-
ribosylation factor (Arf) small GTP-binding proteins, and function to limit the activity of Arf …

Arginine methylation modulates diverse cellular processes and represents a molecular
signature of germ-line-specific Piwi family proteins. A subset of Tudor domains recognize …

Abstract Cool-1 (cloned-out of library 1) has a key role in regulating epidermal growth factor
receptor (EGFR) degradation. Here, we show that Cool-1 performs this function by …

Mutations in the ARHGEF6 gene, encoding the guanine nucleotide exchange factor
αPIX/Cool-2 for the Rho GTPases Rac1 and Cdc42, cause X-linked intellectual disability (ID) …

Over the past 14 years, ubiquitination has emerged as a centrally important mechanism
governing the subcellular trafficking of proteins. Ubiquitination, interaction with sorting …

Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b), a RING finger E3 ubiquitin-protein
ligase, has been demonstrated to play a crucial role in establishing the threshold for T-cell …