Integration of inflammation, fibrosis, and cancer induced by carbon nanotubes

J Dong, Q Ma - Nanotoxicology, 2019 - Taylor & Francis
Carbon nanotubes (CNTs) are nanomaterials with unique physicochemical properties that
are targets of great interest for industrial and commercial applications. Notwithstanding …

A review of toxicity studies of single-walled carbon nanotubes in laboratory animals

M Ema, M Gamo, K Honda - Regulatory Toxicology and Pharmacology, 2016 - Elsevier
We summarized the findings of in vivo toxicity studies of single-walled carbon nanotubes
(SWCNTs) in laboratory animals. The large majority addressed the pulmonary toxicity of …

[HTML][HTML] Interaction of single and multi wall carbon nanotubes with the biological systems: tau protein and PC12 cells as targets

HA Zeinabad, A Zarrabian, AA Saboury, AM Alizadeh… - Scientific reports, 2016 - nature.com
Subtle changes in the structure of nanoparticles influence their surface tension and
corresponding interaction with cells and proteins. Here, the interaction of the single wall …

The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats

S Rittinghausen, A Hackbarth, O Creutzenberg… - Particle and fibre …, 2014 - Springer
Background Biological effects of tailor-made multi-walled carbon nanotubes (MWCNTs)
without functionalization were investigated in vivo in a two-year carcinogenicity study. In the …

Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention

S Toyokuni - Free Radical Biology and Medicine, 2019 - Elsevier
Cancer is the primary cause of human mortality in most countries. This tendency has
increased as various medical therapeutics have advanced, which suggests that we cannot …

The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma …

S Toyokuni - Pathology international, 2016 - Wiley Online Library
Helmut Sies established the concept of oxidative stress in 1985. However, it took some time
to introduce this concept into pathology, where investigators count on formalin‐fixed paraffin …

Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans

ED Kuempel, MC Jaurand, P Møller… - Critical reviews in …, 2017 - Taylor & Francis
In an evaluation of carbon nanotubes (CNTs) for the IARC Monograph 111, the Mechanisms
Subgroup was tasked with assessing the strength of evidence on the potential …

[HTML][HTML] Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary …

L Rahman, NR Jacobsen, SA Aziz, D Wu… - … /Genetic Toxicology and …, 2017 - Elsevier
Abstract The International Agency for Research on Cancer has classified one type of multi-
walled carbon nanotubes (MWCNTs) as possibly carcinogenic to humans. However, the …

Role of oxidative stress in carbon nanotube-generated health effects

P Møller, DV Christophersen, DM Jensen… - Archives of …, 2014 - Springer
The development of products containing carbon nanotubes (CNTs) is a major achievement
of nanotechnology, although concerns regarding risk of toxic effects linger if the hazards …

[HTML][HTML] An integrated approach to testing and assessment of high aspect ratio nanomaterials and its application for grouping based on a common mesothelioma …

F Murphy, S Dekkers, H Braakhuis, L Ma-Hock… - NanoImpact, 2021 - Elsevier
Here we describe the development of an Integrated Approach to Testing and Assessment
(IATA) to support the grouping of different types (nanoforms; NFs) of High Aspect Ratio …