Stroke is the second highest cause of death globally and a leading cause of disability, with
an increasing incidence in developing countries. Ischaemic stroke caused by arterial …

Epidemiological evidence suggests that the incidence of ischaemic stroke in young adults
(18–50 years) has increased substantially. These patients have a long life expectancy after …

Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of
stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share
symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing …

This article is a comprehensive document on the diagnosis and management of
fibromuscular dysplasia (FMD), which was commissioned by the working group …

INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …

Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …

Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for
five vascular diseases, including coronary artery disease, migraine headache, cervical …

Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …