Stem cell-derived retinal organoids offer the opportunity to cure retinal degeneration of wide-
ranging etiology either through the study of in vitro models or the generation of tissue for …

Highlights•A switch from radial migration to dendrite initiation is regulated by local
cues.•Dendrites can select backup synaptic partners when their first choice is missing.•Some …

Loss of primary neuronal inputs inevitably strikes every neural circuit. The deafferented
circuit could propagate, amplify, or mitigate input loss, thus affecting the circuit's output. How …

A major cause of human blindness is the death of rod photoreceptors. As rods degenerate,
synaptic structures between rod and rod bipolar cells disappear and the rod bipolar cells …

The retina is the sensory tissue responsible for the first stages of visual processing, with a
conserved anatomy and functional architecture among vertebrates. To date, retinal eye …

Consistent with their wide distribution throughout the CNS, transcripts of all transient
receptor potential (TRP) cation channel superfamily members have been detected in both …

Quantitative and qualitative evaluation of synapses is crucial to understand neural
connectivity. This is particularly relevant now, in view of the recent advances in regenerative …

The precise specification of cellular fate is thought to ensure the production of the correct
number of neurons within a population. Programmed cell death may be an additional …

The retina is an intricately organized neural tissue built on cone and rod pathways for color
and night vision. Genetic mutations that disrupt the proper function of the rod circuit …

Signals from retinal photoreceptors are processed in two parallel channels—the ON channel
responds to light increments, while the OFF channel responds to light decrements. The ON …