Diabetes Mellitus (DM) is a multi-factorial chronic health condition that affects a large part of
population and according to the World Health Organization (WHO) the number of adults …

To date, non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease,
affecting up to 70% of patients with diabetes. Currently, there are no specific drugs available …

Unimolecular triple incretins, combining the activity of glucagon-like peptide-1 (GLP-1),
glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG), have …

Obesity is a chronic disease with a continuously rising prevalence that currently affects more
than half a billion people worldwide. Energy balance and appetite are highly regulated via …

In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

We report the discovery of a new monomeric peptide that reduces body weight and diabetic
complications in rodent models of obesity by acting as an agonist at three key metabolically …

The preproglucagon gene (Gcg) is expressed by specific enteroendocrine cells (L-cells) of
the intestinal mucosa, pancreatic islet α-cells, and a discrete set of neurons within the …

Aims To characterize the pharmacology of MEDI0382, a peptide dual agonist of glucagon‐
like peptide‐1 (GLP‐1) and glucagon receptors. Materials and methods MEDI0382 was …

Textbook of Diabetes Classic textbook providing diabetologists and endocrinologists with
illustrated and clinically focused content on diabetes Now in its sixth edition, the Textbook of …

Many complex diseases have historically proven to be defiant to the best mono-therapeutic
approaches. Several examples of combination therapies have largely overcome such …