Circadian rhythm as a therapeutic target
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …
changes and internal physiology. The clock endows the host with temporal precision and …
[HTML][HTML] Importance of circadian timing for aging and longevity
VA Acosta-Rodríguez, F Rijo-Ferreira, CB Green… - Nature …, 2021 - nature.com
Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …
can be achieved by controlling how much and/or when food is provided, as well as by …
Circadian regulation of glucose, lipid, and energy metabolism in humans
E Poggiogalle, H Jamshed, CM Peterson - Metabolism, 2018 - Elsevier
The circadian system orchestrates metabolism in daily 24-hour cycles. Such rhythms
organize metabolism by temporally separating opposing metabolic processes and by …
organize metabolism by temporally separating opposing metabolic processes and by …
[HTML][HTML] Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock
G Asher, P Sassone-Corsi - Cell, 2015 - cell.com
The circadian clock, a highly specialized, hierarchical network of biological pacemakers,
directs and maintains proper rhythms in endocrine and metabolic pathways required for …
directs and maintains proper rhythms in endocrine and metabolic pathways required for …
[HTML][HTML] Reprogramming of the circadian clock by nutritional challenge
Circadian rhythms and cellular metabolism are intimately linked. Here, we reveal that a high-
fat diet (HFD) generates a profound reorganization of specific metabolic pathways, leading …
fat diet (HFD) generates a profound reorganization of specific metabolic pathways, leading …
Effect of sleep deprivation on the human metabolome
Sleep restriction and circadian clock disruption are associated with metabolic disorders such
as obesity, insulin resistance, and diabetes. The metabolic pathways involved in human …
as obesity, insulin resistance, and diabetes. The metabolic pathways involved in human …
[HTML][HTML] High-accuracy determination of internal circadian time from a single blood sample
N Wittenbrink, B Ananthasubramaniam… - The Journal of …, 2018 - Am Soc Clin Investig
BACKGROUND. The circadian clock is a fundamental and pervasive biological program that
coordinates 24-hour rhythms in physiology, metabolism, and behavior, and it is essential to …
coordinates 24-hour rhythms in physiology, metabolism, and behavior, and it is essential to …
[HTML][HTML] Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics
Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative
phosphorylation and generation of ATP, are strongly clock controlled. Here we show that …
phosphorylation and generation of ATP, are strongly clock controlled. Here we show that …
Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome
Insufficient sleep and circadian rhythm disruption are associated with negative health
outcomes, including obesity, cardiovascular disease, and cognitive impairment, but the …
outcomes, including obesity, cardiovascular disease, and cognitive impairment, but the …
[HTML][HTML] Chronotype: implications for epidemiologic studies on chrono-nutrition and cardiometabolic health
S Almoosawi, S Vingeliene, F Gachon, T Voortman… - Advances in …, 2019 - Elsevier
Chrono-nutrition is an emerging research field in nutritional epidemiology that encompasses
3 dimensions of eating behavior: timing, frequency, and regularity. To date, few studies have …
3 dimensions of eating behavior: timing, frequency, and regularity. To date, few studies have …