Mechanisms of immunothrombosis in vaccine-induced thrombotic thrombocytopenia (VITT) compared to natural SARS-CoV-2 infection
Herein, we consider venous immunothrombotic mechanisms in SARS-CoV-2 infection and
anti-SARS-CoV-2 DNA vaccination. Primary SARS-CoV-2 infection with systemic viral RNA …
anti-SARS-CoV-2 DNA vaccination. Primary SARS-CoV-2 infection with systemic viral RNA …
Heparin-induced thrombocytopenia
A Greinacher - New England Journal of Medicine, 2015 - Mass Medical Soc
Key Clinical Points Heparin-Induced Thrombocytopenia Heparin-induced thrombocytopenia
(HIT) is characterized by a decrease in the platelet count of more than 50% from the highest …
(HIT) is characterized by a decrease in the platelet count of more than 50% from the highest …
Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia
Vaccine-induced immune thrombotic thrombocytopaenia (VITT) is a rare adverse effect of
COVID-19 adenoviral vector vaccines,–. VITT resembles heparin-induced …
COVID-19 adenoviral vector vaccines,–. VITT resembles heparin-induced …
Microparticles in hemostasis and thrombosis
AP Owens III, N Mackman - Circulation research, 2011 - Am Heart Assoc
Blood contains microparticles (MPs) derived from a variety of cell types, including platelets,
monocytes, and endothelial cells. In addition, tumors release MPs into the circulation. MPs …
monocytes, and endothelial cells. In addition, tumors release MPs into the circulation. MPs …
CXCR3 ligands in disease and therapy
K Van Raemdonck, PE Van den Steen… - Cytokine & growth factor …, 2015 - Elsevier
Chemokines, binding their various G protein-coupled receptors, lead the way for leukocytes
in health and inflammation. Yet chemokine receptor expression is not limited to leukocytes …
in health and inflammation. Yet chemokine receptor expression is not limited to leukocytes …
Heparin-induced thrombocytopenia: a focus on thrombosis
GM Arepally, A Padmanabhan - Arteriosclerosis, thrombosis, and …, 2021 - Am Heart Assoc
Heparin-induced thrombocytopenia is an immune-mediated disorder caused by antibodies
that recognize complexes of platelet factor 4 and heparin. Thrombosis is a central and …
that recognize complexes of platelet factor 4 and heparin. Thrombosis is a central and …
[HTML][HTML] Neutrophil accumulation and NET release contribute to thrombosis in HIT
Heparin-induced thrombocytopenia (HIT) is an immune-mediated thrombocytopenic
disorder associated with a severe prothrombotic state. We investigated whether neutrophils …
disorder associated with a severe prothrombotic state. We investigated whether neutrophils …
Pathogenesis of heparin-induced thrombocytopenia
GM Arepally, DB Cines - Translational Research, 2020 - Elsevier
There are currently no effective substitutes for high intensity therapy with unfractionated
heparin (UFH) for cardiovascular procedures based on its rapid onset of action, ease of …
heparin (UFH) for cardiovascular procedures based on its rapid onset of action, ease of …
Unfractionated heparin versus low molecular weight heparins for avoiding heparin‐induced thrombocytopenia in postoperative patients
DR Junqueira, LM Zorzela… - Cochrane Database of …, 2017 - cochranelibrary.com
Background Heparin‐induced thrombocytopenia (HIT) is an adverse drug reaction
presenting as a prothrombotic disorder related to antibody‐mediated platelet activation. It is …
presenting as a prothrombotic disorder related to antibody‐mediated platelet activation. It is …
COVID-19 versus HIT hypercoagulability
TE Warkentin, S Kaatz - Thrombosis research, 2020 - Elsevier
A striking feature of COVID-19 is the high frequency of thrombosis, particularly in patients
who require admission to intensive care unit because of respiratory complications …
who require admission to intensive care unit because of respiratory complications …