Mechanisms of immunothrombosis in vaccine-induced thrombotic thrombocytopenia (VITT) compared to natural SARS-CoV-2 infection

D McGonagle, G De Marco, C Bridgewood - Journal of autoimmunity, 2021 - Elsevier
Herein, we consider venous immunothrombotic mechanisms in SARS-CoV-2 infection and
anti-SARS-CoV-2 DNA vaccination. Primary SARS-CoV-2 infection with systemic viral RNA …

Heparin-induced thrombocytopenia

A Greinacher - New England Journal of Medicine, 2015 - Mass Medical Soc
Key Clinical Points Heparin-Induced Thrombocytopenia Heparin-induced thrombocytopenia
(HIT) is characterized by a decrease in the platelet count of more than 50% from the highest …

Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia

A Huynh, JG Kelton, DM Arnold, M Daka, I Nazy - Nature, 2021 - nature.com
Vaccine-induced immune thrombotic thrombocytopaenia (VITT) is a rare adverse effect of
COVID-19 adenoviral vector vaccines,–. VITT resembles heparin-induced …

Microparticles in hemostasis and thrombosis

AP Owens III, N Mackman - Circulation research, 2011 - Am Heart Assoc
Blood contains microparticles (MPs) derived from a variety of cell types, including platelets,
monocytes, and endothelial cells. In addition, tumors release MPs into the circulation. MPs …

CXCR3 ligands in disease and therapy

K Van Raemdonck, PE Van den Steen… - Cytokine & growth factor …, 2015 - Elsevier
Chemokines, binding their various G protein-coupled receptors, lead the way for leukocytes
in health and inflammation. Yet chemokine receptor expression is not limited to leukocytes …

Heparin-induced thrombocytopenia: a focus on thrombosis

GM Arepally, A Padmanabhan - Arteriosclerosis, thrombosis, and …, 2021 - Am Heart Assoc
Heparin-induced thrombocytopenia is an immune-mediated disorder caused by antibodies
that recognize complexes of platelet factor 4 and heparin. Thrombosis is a central and …

[HTML][HTML] Neutrophil accumulation and NET release contribute to thrombosis in HIT

K Gollomp, M Kim, I Johnston, V Hayes, J Welsh… - JCI insight, 2018 - ncbi.nlm.nih.gov
Heparin-induced thrombocytopenia (HIT) is an immune-mediated thrombocytopenic
disorder associated with a severe prothrombotic state. We investigated whether neutrophils …

Pathogenesis of heparin-induced thrombocytopenia

GM Arepally, DB Cines - Translational Research, 2020 - Elsevier
There are currently no effective substitutes for high intensity therapy with unfractionated
heparin (UFH) for cardiovascular procedures based on its rapid onset of action, ease of …

Unfractionated heparin versus low molecular weight heparins for avoiding heparin‐induced thrombocytopenia in postoperative patients

DR Junqueira, LM Zorzela… - Cochrane Database of …, 2017 - cochranelibrary.com
Background Heparin‐induced thrombocytopenia (HIT) is an adverse drug reaction
presenting as a prothrombotic disorder related to antibody‐mediated platelet activation. It is …

COVID-19 versus HIT hypercoagulability

TE Warkentin, S Kaatz - Thrombosis research, 2020 - Elsevier
A striking feature of COVID-19 is the high frequency of thrombosis, particularly in patients
who require admission to intensive care unit because of respiratory complications …