Artificial metalloenzymes (ArMs) formed by incorporating synthetic metal catalysts into
protein scaffolds have the potential to impart to chemical reactions selectivity that would be …

Abstract Changes in prolyl oligopeptidase (PREP) expression levels, protein distribution,
and activity correlate with aging and are reported in many neurodegenerative conditions …

Previous studies have shown that prolyl oligopeptidase (PREP) negatively regulates
autophagy and increases the aggregation of alpha-synuclein (αSyn), linking it to the …

Prolyl endopeptidases (PEP) from Sphingomonas capsulata (sc) and Myxococcus xanthus
(mx) selectively degrade gluten peptides in vitro, offering a potential therapeutic strategy for …

Our docking program, Fitted, implemented in our computational platform, Forecaster, has
been modified to carry out automated virtual screening of covalent inhibitors. With this …

Enzymes in the prolyl oligopeptidase family possess unique structures and substrate
specificities that are important for their biological activity and for potential biocatalytic …

Oligopeptidase B cleaves after basic amino acids in peptides up to 30 residues. As a
virulence factor in bacteria and trypanosomatid pathogens that is absent in higher …

Prolyl oligopeptidase (POP) has emerged as a drug target for neurological diseases. A
flexible loop structure comprising loop A (res. 189–209) and loop B (res. 577–608) at the …

Prolyl oligopeptidase (PREP) is conserved in many organisms across life. It is involved in
numerous processes including brain function and neuropathology, that require more than its …

Schizophrenia is a serious life-long disease that affects a significant part of the adult
population. Although there is considerably effective medication for the positive symptoms of …