Nrf2: redox and metabolic regulator of stem cell state and function

X Dai, X Yan, KA Wintergerst, L Cai, BB Keller… - Trends in Molecular …, 2020 - cell.com
Nuclear factor erythroid 2-related factor 2 (Nrf2) is ubiquitously expressed in most eukaryotic
cells and functions to induce a broad range of cellular defenses against exogenous and …

Radiation‐induced normal tissue damage: oxidative stress and epigenetic mechanisms

J Wei, B Wang, H Wang, L Meng… - Oxidative medicine …, 2019 - Wiley Online Library
Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it
may cause damage to healthy tissue, with both short‐term and long‐term side effects …

[HTML][HTML] Isolation and analysis methods of extracellular vesicles (EVs)

Z Zhao, H Wijerathne, AK Godwin… - Extracellular vesicles and …, 2021 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) have been recognized as an evolving biomarker within the
liquid biopsy family. While carrying both host cell proteins and different types of RNAs, EVs …

Radioprotection and radiomitigation: from the bench to clinical practice

E Obrador, R Salvador, JI Villaescusa, JM Soriano… - Biomedicines, 2020 - mdpi.com
The development of protective agents against harmful radiations has been a subject of
investigation for decades. However, effective (ideal) radioprotectors and radiomitigators …

Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis

XL Xue, XD Han, Y Li, XF Chu, WM Miao… - Stem Cell Research & …, 2017 - Springer
Background The hematopoietic system is especially sensitive to total body irradiation (TBI),
and myelosuppression is one of the major effects of TBI. Astaxanthin (ATX) is a powerful …

[HTML][HTML] Long and short non-coding RNA and radiation response: a review

JM May, M Bylicky, S Chopra, CN Coleman… - Translational …, 2021 - Elsevier
Once thought of as arising from “junk DNA,” non-coding RNAs (ncRNAs) have emerged as
key molecules in cellular processes and response to stress. From diseases such as cancer …

Use of biomarkers for assessing radiation injury and efficacy of countermeasures

VK Singh, VL Newman, PLP Romaine… - Expert review of …, 2016 - Taylor & Francis
Several candidate drugs for acute radiation syndrome (ARS) have been identified that have
low toxicity and significant radioprotective and radiomitigative efficacy. Inasmuch as …

DAMPs and radiation injury

S Yamaga, M Aziz, A Murao, M Brenner… - Frontiers in …, 2024 - frontiersin.org
The heightened risk of ionizing radiation exposure, stemming from radiation accidents and
potential acts of terrorism, has spurred growing interests in devising effective …

Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates

W Fendler, B Malachowska, K Meghani… - Science translational …, 2017 - science.org
Effective planning for the medical response to a radiological or nuclear accident is complex.
Because of limited resources for medical countermeasures, the key would be to accurately …

MicroRNA: a novel implication for damage and protection against ionizing radiation

Y Chen, J Cui, Y Gong, S Wei, Y Wei, L Yi - Environmental Science and …, 2021 - Springer
Ionizing radiation (IR) is a form of high energy. It poses a serious threat to organisms, but
radiotherapy is a key therapeutic strategy for various cancers. It is significant to reduce …