Structure and function of mammalian DNA methyltransferases
DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …
regulation, chromatin structure, development and disease. Here, we review the structures …
SET for life: biochemical activities and biological functions of SET domain-containing proteins
HM Herz, A Garruss, A Shilatifard - Trends in biochemical sciences, 2013 - cell.com
SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
PV Kharchenko, AA Alekseyenko, YB Schwartz… - Nature, 2011 - nature.com
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins,
which have an impact on cell differentiation, gene regulation and other key cellular …
which have an impact on cell differentiation, gene regulation and other key cellular …
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation
The Dnmt3a DNA methyltransferase contains in its N-terminal part a PWWP domain that is
involved in chromatin targeting. Here, we have investigated the interaction of the PWWP …
involved in chromatin targeting. Here, we have investigated the interaction of the PWWP …
Signals and combinatorial functions of histone modifications
T Suganuma, JL Workman - Annual review of biochemistry, 2011 - annualreviews.org
Alterations of chromatin structure have been shown to be crucial for response to cell
signaling and for programmed gene expression in development. Posttranslational histone …
signaling and for programmed gene expression in development. Posttranslational histone …
Allosteric control of mammalian DNA methyltransferases–a new regulatory paradigm
A Jeltsch, RZ Jurkowska - Nucleic acids research, 2016 - academic.oup.com
In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains
AA Alekseyenko, EM Walsh, X Wang… - Genes & …, 2015 - genesdev.cshlp.org
NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most
aggressive human solid malignancies known. NMC is driven by the creation of a …
aggressive human solid malignancies known. NMC is driven by the creation of a …
The role of nuclear receptor–binding SET domain family histone lysine methyltransferases in cancer
RL Bennett, A Swaroop… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
The nuclear receptor–binding SET Domain (NSD) family of histone H3 lysine 36
methyltransferases is comprised of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1) …
methyltransferases is comprised of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1) …
Transcription-associated histone modifications and cryptic transcription
M Smolle, JL Workman - Biochimica et Biophysica Acta (BBA)-Gene …, 2013 - Elsevier
Eukaryotic genomes are packaged into chromatin, a highly organized structure consisting of
DNA and histone proteins. All nuclear processes take place in the context of chromatin …
DNA and histone proteins. All nuclear processes take place in the context of chromatin …
Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription
Dosage compensation is an epigenetic mechanism that normalizes gene expression from
unequal copy numbers of sex chromosomes. Different organisms have evolved alternative …
unequal copy numbers of sex chromosomes. Different organisms have evolved alternative …