The initiation of DNA replication represents a committing step to cell proliferation.
Appropriate replication onset depends on multiprotein complexes that help properly …

This review summarizes the mechanisms of the initiator protein DnaA in replication initiation
and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the …

Loading of the replicative DNA helicase at origins of replication is of central importance in
DNA replication. As the first of the replication fork proteins assemble at chromosomal origins …

During the cell division cycle of all bacteria, DNA-protein complexes termed orisomes trigger
the onset of chromosome duplication. Orisome assembly is both staged and stringently …

To initiate DNA replication, DnaA recognizes and binds to specific sequences within the
Escherichia coli chromosomal origin (oriC), and then unwinds a region within oriC. Next …

The initiation of chromosomal DNA replication starts at a replication origin, which in bacteria
is a discrete locus that contains DNA sequence motifs recognized by an initiator protein …

Pluripotency of embryonic stem cells (ESCs) is maintained by transcriptional activities and
chromatin modifying complexes highly organized within the chromatin. Although much effort …

The primary role of the bacterial protein DnaA is to initiate chromosomal replication. The
DnaA protein binds to DNA at the origin of chromosomal replication (oriC) and assembles …

Background Fusobacterium nucleatum is a gram-negative anaerobic species residing in the
oral cavity and implicated in several inflammatory processes in the human body. Although F …

DNA replication is an essential process. Although the fundamental strategies to duplicate
chromosomes are similar in all free-living organisms, the enzymes of the three domains of …