Mechanisms for initiating cellular DNA replication
A Costa, IV Hood, JM Berger - Annual review of biochemistry, 2013 - annualreviews.org
The initiation of DNA replication represents a committing step to cell proliferation.
Appropriate replication onset depends on multiprotein complexes that help properly …
Appropriate replication onset depends on multiprotein complexes that help properly …
The DnaA Cycle in Escherichia coli: Activation, Function and Inactivation of the Initiator Protein
T Katayama, K Kasho, H Kawakami - Frontiers in microbiology, 2017 - frontiersin.org
This review summarizes the mechanisms of the initiator protein DnaA in replication initiation
and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the …
and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the …
Helicase loading at chromosomal origins of replication
SP Bell, JM Kaguni - Cold Spring Harbor perspectives in …, 2013 - cshperspectives.cshlp.org
Loading of the replicative DNA helicase at origins of replication is of central importance in
DNA replication. As the first of the replication fork proteins assemble at chromosomal origins …
DNA replication. As the first of the replication fork proteins assemble at chromosomal origins …
The orisome: structure and function
AC Leonard, JE Grimwade - Frontiers in microbiology, 2015 - frontiersin.org
During the cell division cycle of all bacteria, DNA-protein complexes termed orisomes trigger
the onset of chromosome duplication. Orisome assembly is both staged and stringently …
the onset of chromosome duplication. Orisome assembly is both staged and stringently …
Replication initiation at the Escherichia coli chromosomal origin
JM Kaguni - Current opinion in chemical biology, 2011 - Elsevier
To initiate DNA replication, DnaA recognizes and binds to specific sequences within the
Escherichia coli chromosomal origin (oriC), and then unwinds a region within oriC. Next …
Escherichia coli chromosomal origin (oriC), and then unwinds a region within oriC. Next …
Replication initiation in bacteria
S Chodavarapu, JM Kaguni - The Enzymes, 2016 - Elsevier
The initiation of chromosomal DNA replication starts at a replication origin, which in bacteria
is a discrete locus that contains DNA sequence motifs recognized by an initiator protein …
is a discrete locus that contains DNA sequence motifs recognized by an initiator protein …
Identification of a large protein network involved in epigenetic transmission in replicating DNA of embryonic stem cells
Pluripotency of embryonic stem cells (ESCs) is maintained by transcriptional activities and
chromatin modifying complexes highly organized within the chromatin. Although much effort …
chromatin modifying complexes highly organized within the chromatin. Although much effort …
The role of the N-terminal domains of bacterial initiator DnaA in the assembly and regulation of the bacterial replication initiation complex
A Zawilak-Pawlik, M Nowaczyk… - Genes, 2017 - mdpi.com
The primary role of the bacterial protein DnaA is to initiate chromosomal replication. The
DnaA protein binds to DNA at the origin of chromosomal replication (oriC) and assembles …
DnaA protein binds to DNA at the origin of chromosomal replication (oriC) and assembles …
Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins
Background Fusobacterium nucleatum is a gram-negative anaerobic species residing in the
oral cavity and implicated in several inflammatory processes in the human body. Although F …
oral cavity and implicated in several inflammatory processes in the human body. Although F …
The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery
JM Kaguni - Antibiotics, 2018 - mdpi.com
DNA replication is an essential process. Although the fundamental strategies to duplicate
chromosomes are similar in all free-living organisms, the enzymes of the three domains of …
chromosomes are similar in all free-living organisms, the enzymes of the three domains of …