Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of
vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with …

It is well established that microglial form and function are inextricably linked. In recent years,
the traditional view that microglial form ranges between “ramified resting” and “activated …

Cell surfaces in the immune system are richly equipped with a complex mixture of glycans,
which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of …

Microglia are resident brain cells that sense pathological tissue alterations. They can
develop into brain macrophages and perform immunological functions. However …

Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes).
Through comparison with the human genome, we have generated a largely complete …

All cells in nature are covered by a dense and complex array of carbohydrates. Given their
prominence on cell surfaces, it is not surprising that these glycans mediate and/or modulate …

Gene conversion, one of the two mechanisms of homologous recombination, involves the
unidirectional transfer of genetic material from a'donor'sequence to a highly homologous' …

Despite increasing evidence of major differences between rodent and human immune and
neurological function, relatively few biomedical studies are performed with human cells. This …

A dense and diverse array of glycans on glycoproteins and glycolipids decorate all cell
surfaces. In vertebrates, many of these carry sialic acid, in a variety of linkages and glycan …

Unlike their protein “roommates” and their nucleic acid “cousins," carbohydrates remain an
enigmatic arm of biology. The central reason for the difficulty in fully understanding how …