Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

Lymphoedema is the swelling of one or several parts of the body owing to lymph
accumulation in the extracellular space. It is often chronic, worsens if untreated, predisposes …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

Tissue and vessel wall stiffening alters endothelial cell properties and contributes to
vascular dysfunction. However, whether extracellular matrix (ECM) stiffness impacts …

The lymphatic system plays crucial roles in tissue homeostasis, lipid absorption, and
immune cell trafficking. Although lymphatic valves ensure unidirectional lymph flows, the …

Background: Mutations in PIEZO1 (Piezo type mechanosensitive ion channel component 1)
cause human lymphatic malformations. We have previously uncovered an ORAI1 (ORAI …

The ever-growing research on lymphatic biology has clearly identified lymphatic vessels as
key players that maintain human health through their functional roles in tissue fluid …

The lymphatic vasculature has a pivotal role in regulating body fluid homeostasis, immune
surveillance and dietary fat absorption. The increasing number of in vitro and in vivo studies …

The major function of the lymphatic system is to drain interstitial fluid from tissue. Functional
drainage causes increased fluid flow that triggers lymphatic expansion, which is …

Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals
generated by fluid flow into biological processes. Here, we find that Piezo1 is necessary for …