Postoperative cognitive dysfunction and noncardiac surgery
LA Evered, BS Silbert - Anesthesia & Analgesia, 2018 - journals.lww.com
Postoperative cognitive dysfunction (POCD) is an objectively measured decline in cognition
postoperatively compared with preoperative function. POCD has been considered in the …
postoperatively compared with preoperative function. POCD has been considered in the …
The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment
SA Safavynia, PA Goldstein - Frontiers in psychiatry, 2019 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …
experience and is common in the elderly and patients with preexisting neurocognitive …
Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non‐cardiac surgery
D Miller, SR Lewis, MW Pritchard… - Cochrane Database …, 2018 - cochranelibrary.com
Background The use of anaesthetics in the elderly surgical population (more than 60 years
of age) is increasing. Postoperative delirium, an acute condition characterized by reduced …
of age) is increasing. Postoperative delirium, an acute condition characterized by reduced …
The interface between delirium and dementia in elderly adults
Delirium and dementia are two of the most common causes of cognitive impairment in older
populations, yet their interrelation remains poorly understood. Previous studies have shown …
populations, yet their interrelation remains poorly understood. Previous studies have shown …
Extracellular HMGB1 as a therapeutic target in inflammatory diseases
U Andersson, H Yang, H Harris - Expert opinion on therapeutic …, 2018 - Taylor & Francis
Introduction: High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that
promotes inflammation when released extracellularly after cellular activation, stress …
promotes inflammation when released extracellularly after cellular activation, stress …
The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients
Introduction As the relationship between delirium and long-term cognitive decline has not
been well-explored, we evaluated this association in a prospective study. Methods SAGES …
been well-explored, we evaluated this association in a prospective study. Methods SAGES …
Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study
M Mrkobrada, MTV Chan, D Cowan, D Campbell… - The Lancet, 2019 - thelancet.com
Background In non-surgical settings, covert stroke is more common than overt stroke and is
associated with cognitive decline. Although overt stroke occurs in less than 1% of adults …
associated with cognitive decline. Although overt stroke occurs in less than 1% of adults …
Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction
Background Postoperative delirium in elderly patients is a frequent complication and
associated with poor outcome. The aim of this parallel group study was to determine …
associated with poor outcome. The aim of this parallel group study was to determine …
Role of interleukin‐1β in postoperative cognitive dysfunction
Objective: Although postoperative cognitive dysfunction (POCD) often complicates recovery
from major surgery, the pathogenic mechanisms remain unknown. We explored whether …
from major surgery, the pathogenic mechanisms remain unknown. We explored whether …
Tumor necrosis factor-α triggers a cytokine cascade yielding postoperative cognitive decline
Cognitive decline following surgery in older individuals is a major clinical problem of
uncertain mechanism; a similar cognitive decline also follows severe infection …
uncertain mechanism; a similar cognitive decline also follows severe infection …