Human hypertrophic and keloid scar models: principles, limitations and future challenges from a tissue engineering perspective

LJ van den Broek, GC Limandjaja… - Experimental …, 2014 - Wiley Online Library
Most cutaneous wounds heal with scar formation. Ideally, an inconspicuous normotrophic
scar is formed, but an abnormal scar (hypertrophic scar or keloid) can also develop. A major …

Aberrant wound healing in the horse: naturally occurring conditions reminiscent of those observed in man

CL Theoret, JM Wilmink - Wound repair and regeneration, 2013 - Wiley Online Library
Impaired wound healing represents an enormous clinical and financial problem for
companion animals and humans alike. Unfortunately, most models used to study healing …

HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways

R Lei, J Li, F Liu, W Li, S Zhang, Y Wang, X Chu, J Xu - Cell Cycle, 2019 - Taylor & Francis
ABSTRACT A keloid is defined as an overgrowth of the dense fibrous tissues that form
around a wound. Since they destroy the vascular network, keloid tissues often exhibit anoxic …

[HTML][HTML] Hypoxia-inducible factor-1α activates transforming growth factor-β1/Smad signaling and increases collagen deposition in dermal fibroblasts

X Mingyuan, P Qianqian, X Shengquan, Y Chenyi… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Hypoxia of local tissue occurs during the scar formation; however, the degree of ischemia
and hypoxia in the central areas of keloids is more serious than those in normal scars …

Physiology of wound healing

C Theoret - Equine wound management, 2016 - Wiley Online Library
Prior to undertaking the management of a wound, the underlying biology of wound healing
must be understood so that the best approach at the correct time can be selected, and so …

Hypoxic preconditioning of human urine-derived stem cell-laden small intestinal submucosa enhances wound healing potential

XR Zhang, YZ Huang, HW Gao, YL Jiang… - Stem Cell Research & …, 2020 - Springer
Background Urine-derived stem cells (USCs) are a valuable stem cell source for tissue
engineering because they can be harvested non-invasively. Small intestine submucosa …

In Vitro, Ex Vivo, and In Vivo Approaches for Investigation of Skin Scarring: Human and Animal Models

LMG Neves, TA Wilgus, A Bayat - Advances in Wound Care, 2023 - liebertpub.com
Significance: The cutaneous repair process naturally results in different types of scarring that
are classified as normal or pathological. Affected individuals are often affected from an …

[图书][B] Equine wound management

C Theoret, J Schumacher - 2016 - books.google.com
Now in its third edition, Equine Wound Management is the authoritative resource for both
theoretical and practical information on the care of wounds in horses. The most …

Equine exuberant granulation tissue and human keloids: a comparative histopathologic study

CL Theoret, OO Olutoye, LKS Parnell… - Veterinary …, 2013 - Wiley Online Library
Objective To compare histopathologic features of a fibroproliferative disorder in horses
(exuberant granulation tissue—EGT) and people (keloid). Sample Population Archival tissue …

Fluorinated methacrylamide chitosan hydrogel dressings enhance healing in an acute porcine wound model

PS Patil, MM Evancho-Chapman, H Li, H Huang… - PloS one, 2018 - journals.plos.org
Wound healing involves multiple interrelated processes required to lead to successful
healing outcomes. Phagocytosis, inflammation, cell proliferation, angiogenesis, energy …