Opioid use disorder continues to be a significant source of morbidity and mortality in the
USA and the world. Pharmacologic treatment with methadone and buprenorphine has been …

The central noradrenergic system innervates almost all regions of the brain and, as such, is
well positioned to modulate many neural circuits implicated in behaviors and physiology …

ABSTRACT Introduction: Opioid Use Disorder (OUD) is a significant public health concern,
negatively impacting the medical, psychological, and social domains of an individual's life as …

Objective: To evaluate literature reporting on the role of norepinephrine in alcohol
withdrawal and to determine the safety and efficacy of α2-agonists in reducing symptoms of …

Objectives. To develop evidence-based practice guidelines for the pharmacological
treatment of opioid abuse and dependence. Methods. An international task force of the …

Alcohol Withdrawal Syndrome (AWS) is characterized as the termination of chronic and
sustained alcohol use that leads to severe symptoms of distress or loss of daily functions …

Detoxification refers to the safe discontinuation from a substance of dependence and is
distinct from relapse prevention. Detoxification usually takes between a few days and a few …

Substance use disorders are chronic, relapsing, and harmful conditions characterized by
executive dysfunction. While there are currently no approved pharmacotherapy options for …

Introduction: Opioid withdrawal is a powerful driver of drug-seeking behavior as relief from
this aversive state through drug-taking is a strong negative reinforcer. There are currently …

Objective: To review the pharmacology, efficacy, and safety of lofexidine for the treatment of
opioid withdrawal secondary to the recent Food and Drug Administration (FDA) approval …