Multiple sequence alignment (MSA) is an essential cornerstone in bioinformatics, which can
reveal the potential information in biological sequences, such as function, evolution and …

Large-scale genomics requires highly scalable and accurate multiple sequence alignment
methods. Results collected over this last decade suggest accuracy loss when scaling up …

This review article offers a comprehensive overview of the current understanding of using
metagenomic tools in food microbiome research. It covers the scientific foundation and …

Abstract Classical Zn2+-dependent deac (et) ylases play fundamental regulatory roles in life
and are well characterized in eukaryotes regarding their structures, substrates and …

Motivation Multiple sequence alignment (MSA) is one of the hotspots of current research and
is commonly used in sequence analysis scenarios. However, there is no lasting solution for …

Traditional sequence analysis algorithms fail to identify distant homologies when they lie
beyond a detection horizon. In this review, we discuss how co-evolution-based contact and …

Understanding the origin (s) of life (OoL) is a fundamental challenge for science in the 21st
century. Research on OoL spans many disciplines, including chemistry, physics, biology …

Reformist approaches to multiple sequence alignment (MSA) needed dropping an MSA at
each alignment phase. But it illustrates the evidence of gap scoring rates for exact …

The multiple sequence alignment (MSA) issues are contingent on dropping an MSA to a
rectilinear sketch for every alignment phase. Though, these indicate the damage of …

In this paper, multiple sequence alignment (MSA) is modeled as a two-objective
minimization problem, the score of the alignment serves as an objective, the penalty of the …