The cell cycle inhibitor p21 CDKN1A is a protein playing multiple roles not only in the DNA
damage response, but also in many cellular processes during unperturbed cell growth. The …

NUPR1, or p8 or com1, was first identified from rat pancreas during acute pancreatitis and
later as a gene whose expression was upregulated in metastatic breast cancer cells …

Dysregulated Raf/MEK/extracellular signal-regulated kinase (ERK) signaling, a common
hallmark of tumorigenesis, can trigger innate tumor-suppressive mechanisms, which must …

Nuclear protein 1 (NUPR1/com1/p8) has been shown to interact with transcriptional
regulators such as p300, PTIP, estrogen receptor-β, and SMAD. NUPR1 also has been …

ABSTRACT DHA is a long-chain fatty acid that has potent antiinflammatory properties.
Whereas maternal DHA dietary supplementation has been shown to improve cognitive …

Genotoxic stress activates the phosphatidylinositol 3-kinase-like kinases (PIKKs) that
phosphorylate proteins involved in cell cycle arrest, DNA repair and apoptosis. Previous …

Abstract CIP/KIP and INK4 families of Cyclin-dependent kinase inhibitors (CKIs) are well-
established cell cycle regulatory proteins whose canonical function is binding to Cyclin-CDK …

The most common form of newborn chronic lung disease, bronchopulmonary dysplasia
(BPD), is thought to be caused by oxidative disruption of lung morphogenesis, which results …

Hyperoxia can lead to a myriad of deleterious effects in the lung including epithelial damage
and diffuse inflammation. The specific mechanisms by which hyperoxia promotes these …

Premature infants with bronchopulmonary dysplasia (BPD), are at risk for frequent
respiratory infections and reduced pulmonary function. We studied whether neonatal …