Serving as the basis of cell life, interactions between nucleic acids and proteins play
essential roles in fundamental cellular processes. Aptamers are unique single-stranded …

Antibody-based research applications are critical for biological discovery. Yet there are no
industry standards for comparing the performance of antibodies in various applications. We …

Some exciting biological questions require quantifying thousands of proteins in single cells.
To achieve this goal, we develop Single Cell ProtEomics by Mass Spectrometry (SCoPE …

We convened an ad hoc International Working Group for Antibody Validation in order to
formulate the best approaches for validating antibodies used in common research …

The genetic, functional or compositional heterogeneity of healthy and diseased tissues
presents major challenges in drug discovery and development. Such heterogeneity hinders …

The existence of cellular heterogeneity and its central relevance to biological phenomena
provides a strong rationale for a need for analytical methods that enable analysis at the …

Antibodies are critical reagents to detect and characterize proteins. It is commonly
understood that many commercial antibodies do not recognize their intended targets, but …

Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) is a method
that allows the study of protein complexes, in particular chromatin and transcription factor …

Sirtuins are NAD+-dependent protein deacylases/ADP-ribosyltransferases that have
emerged as candidate targets for new therapeutics to treat metabolic disorders and other …

Nanobodies are single-domain antibodies of camelid origin. We generated nanobodies
against the vertebrate nuclear pore complex (NPC) and used them in STORM imaging to …