Biomedical applications of recombinant silk‐based materials

TB Aigner, E DeSimone, T Scheibel - Advanced materials, 2018 - Wiley Online Library
Silk is mostly known as a luxurious textile, which originates from silkworms first cultivated in
China. A deeper look into the variety of silk reveals that it can be used for much more, in …

Alternative methods of vaccine delivery: an overview of edible and intradermal vaccines

E Criscuolo, V Caputo, RA Diotti… - Journal of …, 2019 - Wiley Online Library
Vaccines are recognized worldwide as one of the most important tools for combating
infectious diseases. Despite the tremendous value conferred by currently available vaccines …

Silkworms transformed with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties

F Teulé, YG Miao, BH Sohn, YS Kim… - Proceedings of the …, 2012 - National Acad Sciences
The development of a spider silk-manufacturing process is of great interest. However, there
are serious problems with natural manufacturing through spider farming, and standard …

MultiBac: expanding the research toolbox for multiprotein complexes

C Bieniossek, T Imasaki, Y Takagi, I Berger - Trends in biochemical …, 2012 - cell.com
Protein complexes composed of many subunits carry out most essential processes in cells
and, therefore, have become the focus of intense research. However, deciphering the …

Protein production using the baculovirus‐insect cell expression system

A Contreras‐Gómez, A Sánchez‐Mirón… - Biotechnology …, 2014 - Wiley Online Library
The baculovirus‐insect cell expression system is widely used in producing recombinant
proteins. This review is focused on the use of this expression system in developing …

Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori

A Tan, G Fu, L Jin, Q Guo, Z Li, B Niu… - Proceedings of the …, 2013 - National Acad Sciences
Transgene-based genetic sexing methods are being developed for insects of agricultural
and public health importance. Male-only rearing has long been sought in sericulture …

Food-grade organisms as vaccine biofactories and oral delivery vehicles

S Rosales-Mendoza, C Angulo, B Meza - Trends in Biotechnology, 2016 - cell.com
The use of food-grade organisms as recombinant vaccine expression hosts and delivery
vehicles has been explored during the past 25 years, opening new avenues for vaccinology …

Preparation of virus-like particle mimetic nanovesicles displaying the S protein of Middle East respiratory syndrome coronavirus using insect cells

T Kato, Y Takami, VK Deo, EY Park - Journal of biotechnology, 2019 - Elsevier
Middle East respiratory syndrome coronavirus (MERS-CoV) first emerged in 2012, and over
2000 infections and 800 deaths have been confirmed in 27 countries. However, to date, no …

Bioengineering of antibody fragments: challenges and opportunities

S Pirkalkhoran, WR Grabowska, HH Kashkoli… - Bioengineering, 2023 - mdpi.com
Antibody fragments are used in the clinic as important therapeutic proteins for treatment of
indications where better tissue penetration and less immunogenic molecules are needed …

[HTML][HTML] Advantages of the silkworm as an animal model for developing novel antimicrobial agents

S Panthee, A Paudel, H Hamamoto… - Frontiers in …, 2017 - frontiersin.org
The demand for novel antibiotics to combat the global spread of multi drug-resistant
pathogens continues to grow. Pathogenic bacteria and fungi that cause fatal human …