Microneedle-mediated vaccination: innovation and translation

T Sheng, B Luo, W Zhang, X Ge, J Yu, Y Zhang… - Advanced drug delivery …, 2021 - Elsevier
Vaccine administration by subcutaneous or intramuscular injection is the most commonly
prescribed route for inoculation, however, it is often associated with some deficiencies such …

Polymeric microneedles for transdermal protein delivery

Y Ye, J Yu, D Wen, AR Kahkoska, Z Gu - Advanced drug delivery reviews, 2018 - Elsevier
The intrinsic properties of therapeutic proteins generally present a major impediment for
transdermal delivery, including their relatively large molecule size and susceptibility to …

Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

AS Rzhevskiy, TRR Singh, RF Donnelly… - Journal of controlled …, 2018 - Elsevier
Microneedles is the technique of drug delivery enhancement, which was primarily designed
for facilitating percutaneous drug delivery. Started from the development of simple solid …

Skin permeabilization for transdermal drug delivery: recent advances and future prospects

CM Schoellhammer, D Blankschtein… - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: Transdermal delivery has potential advantages over other routes of
administration. It could reduce first-pass metabolism associated with oral delivery and is less …

Enterotoxigenic Escherichia coli in Developing Countries: Epidemiology, Microbiology, Clinical Features, Treatment, and Prevention

F Qadri, AM Svennerholm, ASG Faruque… - Clinical microbiology …, 2005 - Am Soc Microbiol
SUMMARY ETEC is an underrecognized but extremely important cause of diarrhea in the
developing world where there is inadequate clean water and poor sanitation. It is the most …

Transdermal delivery systems for biomolecules

MC Peña-Juárez, OR Guadarrama-Escobar… - Journal of …, 2021 - Springer
Purpose The present review article focuses on highlighting the main technologies used as
tools that improve the delivery of transdermal biomolecules, addressing them from the point …

Needle-free vaccine delivery

EL Giudice, JD Campbell - Advanced drug delivery reviews, 2006 - Elsevier
The search for methods of vaccine delivery not requiring a needle and syringe has been
accelerated by recent concerns regarding pandemic disease, bioterrorism, and disease …

Recent advances in the discovery and delivery of vaccine adjuvants

DT O'Hagan, NM Valiante - Nature Reviews Drug Discovery, 2003 - nature.com
Adjuvant design has historically had a touch of alchemy at its heart due to its reliance on the
complex biology of innate immune activation. However, a new mechanistic understanding of …

Elastic liposomes as novel carriers: recent advances in drug delivery

A Hussain, S Singh, D Sharma, TJ Webster… - International journal …, 2017 - Taylor & Francis
Elastic liposomes (EL) are some of the most versatile deformable vesicular carriers that
comprise physiologically biocompatible lipids and surfactants for the delivery of numerous …

Immunization without needles

S Mitragotri - Nature Reviews Immunology, 2005 - nature.com
Most current immunization procedures make use of needles and syringes for vaccine
administration. With the increase in the number of immunizations that children around the …