Exosomes are small membranous vesicles secreted by a number of cell types including
neurons and can be isolated from conditioned cell media or bodily fluids such as urine and …

Prions, which cause fatal neurodegenerative disorders such as Creutzfeldt‐Jakob disease,
are misfolded and infectious protein aggregates. Currently, there are no treatments available …

The misfolding and aggregation of endogenous proteins in the central nervous system is a
neuropathological hallmark of Alzheimer's disease (AD), Parkinson's disease (PD), as well …

Cell-based measurement of prion infectivity is currently restricted to experimental strains of
mouse-adapted scrapie. Having isolated cell cultures with susceptibility to prions from …

Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal
neurodegenerative disorders in mammals that are caused by unconventional agents …

Cell-to-cell transfer of prions is a crucial step in the spreading of prion infection through
infected tissue. At the cellular level, several distinct pathways including direct cell–cell …

Prions are unconventional agents composed of misfolded prion protein that cause fatal
neurodegenerative diseases in mammals. Prion strains induce specific neuropathological …

Due to recent renewal of interest and concerns in prion diseases, a number of cell systems
permissive to prion multiplication have been generated in the last years. These include …

Prion diseases are fatal neurodegenerative diseases caused by misfolding of the prion
protein (PrP). These conditions affect humans and animals, including endemic forms in …

The bank vole (BV) prion protein (PrP) can function as a universal acceptor of prions.
However, the molecular details of BVPrP's promiscuity for replicating a diverse range of …