Development of idiosyncratic hepatotoxicity is an intricate process involving both concurrent
as well as sequential events determining the direction of the pathways, degree of liver injury …

Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause
liver injury and even liver failure. INH metabolism has been thought to be associated with …

Current drug-safety assays for hepatotoxicity rely on biomarkers with low predictive power.
The production of radical species, specifically reactive oxygen species (ROS) and reactive …

The microenvironments of biological systems are associated with the pathology of
organisms. This study, aimed to construct a hemicyanine-based probe (1), which can …

Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Naphthalene, a cytotoxic moiety, is an extensively explored aromatic conjugated system with
applications in various pathophysiological conditions viz. anticancer, antimicrobial, anti …

Mitochondrial dysfunction is increasingly implicated in the etiology of drug-induced toxicities.
Members of diverse drug classes undermine mitochondrial function, and among the most …

Drug-induced liver injury is a significant and still unresolved clinical problem. Limitations to
knowledge about the mechanisms of toxicity render incomplete the detection of hepatotoxic …

Idiosyncratic drug-induced liver injury (DILI) is a major clinical problem and poses a
considerable challenge for drug development as an increasing number of successfully …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …