Fms-like tyrosine kinase 3 (FLT3) is an important member of the class III receptor tyrosine
kinase (RTK) family, which is involved in the proliferation of hematopoietic cells and …

Fms-like tyrosine kinase 3 (FLT3) mutation mechanisms are among the most common
genetic abnormalities detected in about 30% of acute myeloid leukemia (AML) patients …

Hepatic fibrosis remains a great challenge clinically. The orphan nuclear receptor Nur77 is
recently suggested as the critical regulator of transforming growth factor-β (TGF-β) signaling …

Melanoma is a type of skin cancer that originates in the pigment-producing cells of the body
known as melanocytes. Most genetic aberrations in melanoma result in hyperactivation of …

Background Phytoene dehydrogenase (PDS) and p-hydroxyphenylpyruvate dioxygenase
(HPPD) are two important herbicides targets in photosynthesis. If inhibiting the activity of …

Introduction: The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are
switched on by the oncogenic MAPK (ERK) signalling pathway. They phosphorylate …

Acute myeloid leukemia (AML) is a malignant disease characterized by abnormal growth
and differentiation of hematopoietic stem cells. Although the pathogenesis has not been fully …

Simple Summary CDDD11-8 is an orally bioactive pharmacological inhibitor of CDK9. In
AML cells, CDDD11-8 suppressed the proliferation and caused robust inhibition of tumor …

Fms-like tyrosine kinase 3 (FLT3) is considered a promising therapeutic target for acute
myeloid leukemia (AML) in the clinical. However, monotherapy with FLT3 inhibitor is usually …

The mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1 and MNK2)
phosphorylate eukaryotic initiation factor 4E (eIF4E) and play important roles in promoting …