Bee updated: current knowledge on bee venom and bee envenoming therapy

MB Pucca, FA Cerni, IS Oliveira, TP Jenkins… - Frontiers in …, 2019 - frontiersin.org
Honey bees can be found all around the world and fulfill key pollination roles within their
natural ecosystems, as well as in agriculture. Most species are typically docile, and most …

Amplification of snake venom toxicity by endogenous signaling pathways

PE Bickler - Toxins, 2020 - mdpi.com
The active components of snake venoms encompass a complex and variable mixture of
proteins that produce a diverse, but largely stereotypical, range of pharmacologic effects and …

[HTML][HTML] Analytical strategies in venomics

J Slagboom, C Kaal, A Arrahman, FJ Vonk… - Microchemical …, 2022 - Elsevier
Snakebite envenoming is a major issue in certain developing parts of the world, with tens of
thousands of deaths and a multitude of lingering permanent medical conditions on a yearly …

Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors

RH Clare, CA Dawson, A Westhorpe… - Frontiers in …, 2024 - frontiersin.org
Snakebite envenoming results in∼ 100,000 deaths per year, with close to four times as
many victims left with life-long sequelae. Current antivenom therapies have several …

[HTML][HTML] Snake venom vascular endothelial growth factors (svVEGFs): Unravelling their molecular structure, functions, and research potential

IG Ferreira, MB Pucca, IS de Oliveira, FA Cerni… - Cytokine & Growth …, 2021 - Elsevier
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis, a
physiological process characterized by the formation of new vessels from a preexisting …

Comprehensive study of the proteome and transcriptome of the venom of the most venomous european viper: Discovery of a new subclass of ancestral snake venom …

A Leonardi, T Sajevic, J Pungerčar… - Journal of proteome …, 2019 - ACS Publications
The nose-horned viper, its nominotypical subspecies Vipera ammodytes ammodytes (Vaa),
in particular, is, medically, one of the most relevant snakes in Europe. The local and …

Effect of the phospholipase A2 inhibitor Varespladib, and its synergism with crotalic antivenom, on the neuromuscular blockade induced by Crotalus durissus terrificus …

J de Souza, ICF Oliveira, EH Yoshida, NM Cantuaria… - Toxicon, 2022 - Elsevier
The venom of the South American rattlesnake Crotalus durissus terrificus causes an
irreversible neuromuscular blockade in isolated preparations due to action of the …

Pan-American Lancehead Pit-Vipers: Coagulotoxic Venom Effects and Antivenom Neutralisation of Bothrops asper and B. atrox Geographical Variants

LA Bourke, CN Zdenek, E Neri-Castro, M Bénard-Valle… - Toxins, 2021 - mdpi.com
The toxin composition of snake venoms and, thus, their functional activity, can vary between
and within species. Intraspecific venom variation across a species' geographic range is a …

Proteomic Characterization of Two Medically Important Malaysian Snake Venoms, Calloselasma rhodostoma (Malayan Pit Viper) and Ophiophagus hannah (King …

S Kunalan, I Othman, S Syed Hassan, WC Hodgson - Toxins, 2018 - mdpi.com
Calloselasma rhodostoma (CR) and Ophiophagus hannah (OH) are two medically important
snakes found in Malaysia. While some studies have described the biological properties of …

Clinical, Laboratory, and Therapeutic Aspects of Crotalus durissus (South American Rattlesnake) Victims: A Literature Review

BT Frare, YK Silva Resende… - BioMed research …, 2019 - Wiley Online Library
Snakebite envenoming is a neglected public health issue in many tropical and subtropical
countries. To diagnosis and treat snakebites may be challenging to health care personnel …